Genevoyager has a professional team specialized in pharmacodynamic evaluation. With years of experience and a well-established pharmacology research platform, we can provide cell-based pharmacodynamic studies and in vivo pharmacodynamic studies using different disease models, tailored to customer needs. These services contribute to elucidating the mechanisms of pharmacodynamic effects and facilitating clinical translation research.
〓 In vivo pharmacodynamic evaluation
Genevoyager has established a comprehensive platform for constructing animal disease models, covering a wide range of diseases including neurological disorders, endocrine system disorders, respiratory/digestive system disorders, cardiovascular system disorders, rheumatic autoimmune diseases, and metabolic disorders. Detailed disease models are listed in the table below.
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Category |
Disease Models |
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Nervous System Diseases
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● Parkinson’s disease model
● Alzheimer’s disease model
● Aging and dementia models
● Brain ischemia/hemorrhage/stroke model
● Demyelinating disease model
● Depression model
● Epilepsy model
● Anxiety model
● Learning and memory model
● Schizophrenia model
● Pain disease model
● Drug addiction model
● Huntington’s disease model
● Migraine model
● Autism model
● Spinal cord injury model
● Amyotrophic lateral sclerosis (ALS) model
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Endocrine System Diseases
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● DIO (diet-induced obesity) model ● Metabolic liver disease model ● DIO+STZ-induced T2MD model ● Spontaneous diabetes model ● Familial hypercholesterolemia model ● B6-OB spontaneous obesity/diabetes model ● LEPR gene knockout model ● Multiple endocrine neoplasia model |
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Respiratory/Digestive System Diseases
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● Idiopathic pulmonary fibrosis model ● Wilson Disease (WD) model ● Non-alcoholic fatty liver disease (NAFLD) model ● Gastric ulcer model ● Intestinal motility model ● Ulcerative colitis model |
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Cardiovascular System Diseases
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● Atherosclerosis model ● Myocardial ischemia model ● Aortic dissection model ● Hypertension model ● Heart failure model ● Cardiac hypertrophy model |
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Rheumatic Autoimmune Diseases
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● Inflammatory bowel disease model ● Rheumatoid arthritis model ● Experimental autoimmune encephalomyelitis (EAE) model ● Psoriasis model |
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Metabolic Diseases
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● Obesity model ● Diabetes model ● Non-alcoholic liver disease model ● Alcoholic liver disease model ● Hyperlipidemia model ● Hyperuricemia model ● Acute gout model ● Sepsis model ● Cholestasis model |
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Eye Diseases
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● Photoreceptor injury model ● Chronic high intraocular pressure model ● Acute retinal ganglion cell death model ● Optic nerve crush injury model ● Hypoxia-induced retinal neovascularization model ● Laser-induced choroidal neovascularization model ● Alkali burn-induced corneal neovascularization model ● Age-related macular degeneration model |
|
Ear Diseases
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● Transtympanic administration ● Round window membrane intracochlear drug delivery |
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Urinary System/Kidney Diseases
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● Gentamicin-induced acute kidney injury model ● Cisplatin-induced kidney disease model ● Prostate hyperplasia model ● Propionic acid-induced prostate model ● Castration model ● Renal fibrosis model ● Renal failure model |
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Musculoskeletal Disorders
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● Arthritis model ● Osteoporosis model |
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Tumor
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● Carcinoma in situ ● Subcutaneously transplanted tumor ● Hematologic tumor ● CDX model |
〓 In vitro pharmacodynamic testing
Genevoyager provides in vitro pharmacodynamic testing services for various types of drugs, including nucleic acid and protein testing, cell autophagy assay, cell proliferation assay, cell apoptosis assay, cell motility assay, and other experiments or assays. Please refer to the table below for detailed testing projects.
|
Category |
Testing Items |
|
Nucleic Acid and Protein Testing
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● qPCR testing ● WB testing ● ELISA testing ● RNA m6A methylation testing ● IP testing ● Co-IP testing |
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Cell Autophagy Assays
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● Electron microscopy observation of autophagosome formation ● GFP-LC3 fusion protein tracing |
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Cell Proliferation Assays
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● ATP concentration assay ● EdU / Brdu staining ● Proliferation-related antigen detection ● CCK-8 assay ● Flow cytometry for cell cycle ● MTT assay |
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Cell Apoptosis Assays
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● TUNEL staining ● Flow cytometry for apoptosis ● Caspase3 activity assay |
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Cell Motility Assays
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● TUNEL staining ● Flow cytometry for apoptosis ● Caspase3 activity assay |
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Other Experiments or Assays
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● Flow cytometry for apoptosis ● Caspase3 activity assay ● Flow cytometry for cell surface antigen detection ● Mitochondrial membrane potential assay ● Angiogenesis assay ● Cell adhesion assay ● Cell immunofluorescence detection ● Oxidative stress assessment ● Biochemical assay ● Calcium ion concentration detection |
US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com
China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com
US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com
China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com
